Premium
Neuroscience and accelerator mass spectrometry
Author(s) -
Palmblad Magnus,
Buchholz Bruce A.,
Hillegonds Darren J.,
Vogel John S.
Publication year - 2005
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.734
Subject(s) - accelerator mass spectrometry , chemistry , mass spectrometry , bioavailability , biomedicine , pharmacokinetics , pharmacology , chromatography , bioinformatics , medicine , biology
Accelerator mass spectrometry (AMS) is a mass spectrometric method for quantifying rare isotopes. It has had a great impact in geochronology and archaeology and is now being applied in biomedicine. AMS measures radioisotopes such as 3 H, 14 C, 26 Al, 36 Cl and 41 Ca, with zepto‐ or attomole sensitivity and high precision and throughput, allowing safe human pharmacokinetic studies involving microgram doses, agents having low bioavailability or toxicology studies where administered doses must be kept low (<1 µg kg −1 ). It is used to study long‐term pharmacokinetics, to identify biomolecular interactions, to determine chronic and low‐dose effects or molecular targets of neurotoxic substances, to quantify transport across the blood–brain barrier and to resolve molecular turnover rates in the human brain on the time‐scale of decades. We review here how AMS is applied in neurotoxicology and neuroscience. Copyright © 2005 John Wiley & Sons, Ltd.