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Application of a multi‐turn time‐of‐flight mass spectrometer, MULTUM II, to organic compounds ionized by matrix‐assisted laser desorption/ionization
Author(s) -
Okumura Daisuke,
Toyoda Michisato,
Ishihara Morio,
Katakuse Itsuo
Publication year - 2004
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.575
Subject(s) - chemistry , mass spectrometry , ionization , resolution (logic) , analytical chemistry (journal) , ion , desorption , time of flight , ion source , time of flight mass spectrometry , spectrometer , laser , matrix assisted laser desorption electrospray ionization , matrix (chemical analysis) , thermal ionization mass spectrometry , optics , chromatography , physics , organic chemistry , adsorption , artificial intelligence , computer science
The circuit shape of the ion path, or the multi‐turn, provides a solution for achieving unrestricted mass resolution from time‐of‐flight mass analyzers. The potential of a multi‐turn type mass spectrometer, the MULTUM II, with a 1.308 m circuit controlled by four toroidal electric sector fields in biological applications was examined. With matrix‐assisted laser desorption/ionization, the ion flight of 18 cycles gave a mass resolution of 10 000 for MH + of protophorphyrin IX. This resolution was correlated with the flight length, and a resolution of 61 000 was achieved for MH + of angiotensin I after 75 cycles or a 98.75 m total flight. The results demonstrate that the multi‐turn mass spectrometer allows not only high resolution but also very high separation of the ions of molecular species from organic compounds. Copyright © 2004 John Wiley & Sons, Ltd.