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Contactless electrospray ionization mass spectrometry for direct detection of analytes in living organisms
Author(s) -
Li Wen,
Yao YaNan,
Wu Lin,
Wang Lei,
Hu Bin
Publication year - 2021
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.4539
Subject(s) - chemistry , electrospray ionization , mass spectrometry , analyte , electrospray , chromatography , in vivo , organism , extractive electrospray ionization , ionization , desorption electrospray ionization , analytical chemistry (journal) , chemical ionization , sample preparation in mass spectrometry , ion , organic chemistry , paleontology , microbiology and biotechnology , biology
In this study, we developed contactless electrospray ionization mass spectrometry (ESI‐MS) for in vivo analysis of living organisms in different applications. The in vivo sampling and direct analysis processess of living organisms were integrated into an operation that only requires the organism close to MS inlet that was applied to a high voltage. Living plants and animals were directly induced to generate spray ionization. Direct detection and in vivo monitoring of metabolites and chemical residues in various living organisms were successfully demonstrated. Analysis of a single sample could be completed within 30 s. Overall, contactless ESI‐MS provides an attractive in vivo method to straightforward investigation of living organisms.