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Paper spray tandem mass spectrometry: A rapid approach for the assay of parabens in cosmetics and drugs
Author(s) -
Bartella Lucia,
Di Donna Leonardo,
Napoli Anna,
Sindona Giovanni,
Mazzotti Fabio
Publication year - 2020
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.4526
Subject(s) - chemistry , chromatography , analyte , reproducibility , calibration curve , paraben , isotope dilution , tandem mass spectrometry , cosmetics , mass spectrometry , selected reaction monitoring , calibration , standard curve , bioanalysis , analytical chemistry (journal) , detection limit , preservative , statistics , food science , mathematics , organic chemistry
A fast methodology for the assay of parabens in drug and cosmetic preparations has been presented. The procedure developed is based on paper spray tandem mass spectrometry and isotope dilution approach. For each investigated paraben, the corresponding labeled standard has been used in order to improve the accuracy and reproducibility of the analyses. The MS experiments have been performed under MRM conditions, monitoring the transitions [M‐H] − → m/z 92 and [M‐H] − → m/z 98, respectively, for each analyte and the corresponding labeled internal standard. The quantitative assay has been performed using a calibration curve built from 2 to 15 mg/L. The method accuracy, in all case near 100%, was evaluated using fortified samples at two concentration levels, which are representative of the lower and the higher portion of calibration curve. The good values of LOQ, LOD, and reproducibility confirm the consistency of the developed approach.