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Selective adduct formation by furan chemical ionization reagent in gas chromatography ion trap mass spectrometry
Author(s) -
Tzing ShinHwa,
Ghule Anil,
Chang JiaYaw,
Ling YongChien
Publication year - 2003
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.452
Subject(s) - chemistry , chemical ionization , mass spectrometry , furan , adduct , electron ionization , reagent , substituent , selectivity , ion trap , chromatography , medicinal chemistry , ion , organic chemistry , ionization , catalysis
The analytical potential of furan as a chemical ionization (CI) reagent was evaluated for selectivity with nine monosubstituted naphthalene compounds. The ion–molecule reactions of furan and tetrahydrofuran (THF) were compared with those of methane, methanol and acetonitrile (prominently producing [M + H] + ion base peaks) with naphthalene compounds in chemical ionization mass spectrometry (CI‐MS). Reactions with furan predominantly show M + and [M + 39] + ions. Based on this phenomenon, investigations were carried out for some of the molecular factors such as proton affinity, substituent effects and the preferred site of [C 3 H 3 ] + ion attachment that influence reactivity in furan CI. High selectivity with different substituents is observed in the formation of [M + 39] + adduct ion, suggesting its usefulness as selective ionization reagent liquid. The selectivity and sensitivity are illustrated in the analysis of mixture of amino acids. Furthermore, the structure determination and reaction mechanism study is characterized by collision‐activated dissociation experiments in CI‐MS/MS and CI‐MS/MS/MS. Copyright © 2003 John Wiley & Sons, Ltd.