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Is the placental proteome impaired in well‐controlled gestational diabetes?
Author(s) -
Burlina Silvia,
Banfi Cristina,
Brioschi Maura,
Visentin Silvia,
Dalfrà Maria Grazia,
Traldi Pietro,
Lapolla Annunziata
Publication year - 2019
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.4336
Subject(s) - gestational diabetes , placenta , proteome , chemistry , glycemic , pregnancy , diabetes mellitus , pathological , endocrinology , medicine , andrology , gestation , fetus , biochemistry , biology , genetics
In pregnancy complicated by gestational diabetes mellitus (GDM), the human placenta shows several pathological functional and structural changes, but the extent to which maternal glycemic control contributes to placental abnormalities remains unclear. The aim of this study was to profile and compare the proteome of placentas from healthy pregnant women and those with GDM, to investigate the placenta‐specific protein composition and possible changes of its function in presence of GDM. Quantitative proteomic analysis, based on LC‐MS E approach, revealed that higher (approximately 15% increase) levels of galectin 1 and collagen alpha‐1 XIV chain (although the difference regarding the latter was at the limit of significance) were present in GDM samples, while heat shock 70 kDa protein 1A/1B was less abundant in GDM placental tissue. These data seem to indicate that GDM, when well controlled, did not markedly affect the placental proteome.