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Gold nanoparticles for enhanced ionization and fragmentation of biomolecules using LDI‐MS
Author(s) -
Sacks Cody D.,
Stumpo Katherine A.
Publication year - 2018
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.4282
Subject(s) - chemistry , biomolecule , fragmentation (computing) , colloidal gold , ionization , electron ionization , mass spectrometry , mass spectrum , chemical ionization , nanoparticle , desorption , photoionization , atmospheric pressure laser ionization , ambient ionization , molecule , analytical chemistry (journal) , nanotechnology , ion , chromatography , adsorption , organic chemistry , biochemistry , materials science , computer science , operating system
New applications for gold nanoparticles (AuNPs) in laser desorption ionization mass spectrometry are presented here. This work expands on previous biomolecule studies and introduces carbohydrates, steroids, bile acids, and other small molecules as a focus. Broad trends in ionization are observed, and specifically of interest are new species that have not previously been reported from AuNPs (e.g., [M + Au] + ). Interesting fragmentation effects have been observed for diphenhydramine, including similarity to electron impact mass spectra and possible radical driven reactions, providing insight into the mechanism of ionization when using AuNPs.