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Accelerated reactions in field desorption mass spectrometry
Author(s) -
Chen Xingshuo,
Cooks R. Graham
Publication year - 2018
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.4254
Subject(s) - chemistry , reagent , mass spectrometry , desorption electrospray ionization , field desorption , reaction rate , fragmentation (computing) , mass spectrum , hydrazone , analytical chemistry (journal) , chemical ionization , hydrazine (antidepressant) , radical , inorganic chemistry , photochemistry , ionization , organic chemistry , ion , chromatography , catalysis , operating system , computer science
Field desorption mass spectrometry under ambient conditions is used to study solution‐phase organic reactions in micro‐volumes. Reagent solution is transferred onto the microdendrites of the field emitter, and reaction products are examined online by mass spectrometry. Three reactions, hydrazone formation by phenyl hydrazine and indoline‐2,3‐dione, the Katritzky reaction between a pyrylium salt and anisidine, and the Hantzsch synthesis of 1,4‐dihydropyridine, were investigated, and reaction acceleration was observed to different extents. The increase in rate relative to the corresponding bulk reactions is attributed to solvent evaporation (simple concentration effect) and to the increase of surface‐to‐volume ratio (enhanced interfacial reactions). A distinguishing feature of this method of reaction acceleration, relative to that based on nano electrospray ionization, is the observation of radical cations and the formation of radical cation products. The study also breaks new ground in using field emitters at atmospheric pressure.