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A fast and simple approach for the quantification of 40 illicit drugs, medicines, and pesticides in blood and urine samples by UHPLC‐MS/MS
Author(s) -
Franco de Oliveira Sarah C. W. S. E.,
Zucoloto Alexandre D.,
Oliveira Carolina D. R.,
Hernandez Edna M. M.,
Fruchtengarten Ligia V. G.,
Oliveira Tiago F.,
Yonamine Mauricio
Publication year - 2019
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.4232
Subject(s) - context (archaeology) , urine , chemistry , triage , emergency medicine , analyte , chromatography , medicine , paleontology , biochemistry , biology
Based on data collected by the “Information System on Diseases of Compulsory Declaration”, an agency responsible for poisoning notifications in Brazil, just short of 500,000 humans in that country were exposed to xenobiotics during the period 2013‐2017. The most commonly detected substances included medications (e.g., analgesics, benzodiazepines, antidepressants, anticonvulsants), drugs of abuse and pesticides.In this month's Special Feature, a group of investigators report a fast and simple UHPLC‐MS/MS approach for the quantification of 40 of the most important components in the context of emergency toxicology in Brazil. The method reported by Dr. Franco de Oliveira and colleagues is applicable to the analysis of both blood and urine samples. When their method was applied to 320 samples collected at the Poison Control Center, São Paulo, between December 2014 and December 2017, almost 90% of these (i.e., 285/320) tested positive for one or more of the targeted analytes. Of these samples, 58 were positive for blood only, 22 were positive for urine only, and the remaining 205 were positive for both matrices. Of the positive blood samples, 27 shown a concentration higher than the therapeutic or normal ranges. The authors suggest their method delivers the sensitivity, selectivity and speed necessary to aid in the emergency room triage process and to improve emergency healthcare outcomes in a busy hospital setting.