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Digital mass filter analysis in stability zones A and B
Author(s) -
Opačić B.,
Huntley A. P.,
Clowers B. H.,
Reilly P. T. A.
Publication year - 2018
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.4019
Subject(s) - chemistry , mass spectrometry , stability (learning theory) , filter (signal processing) , duty cycle , range (aeronautics) , nanotechnology , analytical chemistry (journal) , engineering physics , voltage , electrical engineering , computer science , engineering , aerospace engineering , chromatography , materials science , machine learning
For most of us, the principles and intricate functioning of a given mass analyzer sometimes remain elusive. However, it is only through the understanding of these principles that full ion manipulation possibilities can be exploited resulting in high quality MS data. In this regard, digital waveform technology (DWT) is emerging as a powerful tool in MS. Digital quadrupoles rely on precise control of frequency rather than voltage, which allows these devices to access a greatly extended mass range. In this special feature, Peter Reilly and colleagues present their work with DWT analysis by examining low mass range limitations and their causes and provide a tutorial of the use of the stability diagrams and well depth plots. These are used to show how changing the duty cycle affects radial and axial stability and creates and manipulates mass windows. These concepts were used to examine mass analysis in the zone B stability region and mass analyses performed on a digitally‐operated quadrupolar mass filter were used for demonstration. Dr Reilly is Associate Professor of chemistry at Washington State University (Pullman, WA). His research interests are focused on the development and applications of ultrahigh mass spectrometry out to the billion Da range and beyond.