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Fragmentation behavior of DOTA complexes under different activation conditions
Author(s) -
Beck S.,
Trog S.,
Knizia S.,
Linscheid M. W.
Publication year - 2017
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.3942
Subject(s) - chemistry , dissociation (chemistry) , fragmentation (computing) , lanthanide , metal , indium , mass spectrometry , electrospray ionization , ion , collision induced dissociation , ionization , analytical chemistry (journal) , inorganic chemistry , tandem mass spectrometry , organic chemistry , chromatography , computer science , operating system
We have investigated the fragmentation behavior of a number of DOTA‐metal complexes under collision‐induced dissociation, infrared‐multiphoton dissociation and higher‐energy collisional dissociation activation conditions. Both, positive and negative ion mode electrospray ionization was applied. The results show that characteristic fragmentations were obtained for the metal‐complexes under the investigated conditions. All elemental compositions of fragment ions have been unambiguously identified by high resolution‐accurate mass measurements. Certain trends, for instance eliminations of carbon dioxide, alkyl and amine residues, were observed that coincide with the size of the metal and its location within the periodic table. Additionally, lanthanide, aluminium and indium species with even oxidation state or containing a radical have been detected. To further investigate the observed water capture during activation, deuterium labeling experiments have also been carried out. Copyright © 2017 John Wiley & Sons, Ltd.