Premium
ESI‐MS studies of the non‐covalent interactions between biologically important metal ions and N ‐sulfonylcytosine derivatives
Author(s) -
Ključarić Valentina,
Kobetić Renata,
Rinkovec Jasmina,
Kazazić Snježana,
Gembarovski Dubravka,
Saftić Dijana,
Matić Josipa,
Ban Željka,
Žinić Biserka
Publication year - 2016
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.3810
Subject(s) - chemistry , electrospray ionization , covalent bond , ligand (biochemistry) , metal , metal ions in aqueous solution , alkali metal , ion , non covalent interactions , mass spectrometry , tris , inorganic chemistry , stereochemistry , crystallography , medicinal chemistry , molecule , organic chemistry , hydrogen bond , chromatography , biochemistry , receptor
The aim of this report is to present the electrospray ionization mass spectrometry results of the non‐covalent interaction of two biologically active ligands, N ‐1 ‐ ( p‐ toluenesulfonyl)cytosine, 1‐TsC, 1 and N ‐1 ‐ methanesulfonylcytosine, 1‐MsC, 2 and their Cu(II) complexes Cu(1‐TsC‐ N3 ) 2 Cl 2 , 3 and Cu(1‐MsC‐ N3 ) 2 Cl 2 and 4 with biologically important cations: Na + , K + , Ca 2+ , Mg 2+ and Zn 2+ . The formation of various complex metal ions was observed. The alkali metals Na + and K + formed clusters because of electrostatic interactions. Ca 2+ and Mg 2+ salts produced the tris ligand and mixed ligand complexes. The interaction of Zn 2+ with 1–4 produced monometal and dimetal Zn 2+ complexes as a result of the affinity of Zn 2+ ions toward both O and N atoms. Copyright © 2016 John Wiley & Sons, Ltd.