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A novel method for determination of inorganic oxyanions by electrospray ionization mass spectrometry using dehydration reactions
Author(s) -
Kojima Hirochika,
Kurihara Shota,
Watanabe Yoshito,
Iwamaru Koki,
Sato Kiichi,
Tsunoda Kinichi,
Hotta Hiroki
Publication year - 2016
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.3731
Subject(s) - chemistry , nitrilotriacetic acid , dehydration , mass spectrometry , dehydration reaction , detection limit , electrospray ionization , chromatography , nuclear chemistry , inorganic chemistry , chelation , biochemistry
Novel methods for the determination of inorganic oxyanions by electrospray (ES) ionization mass spectrometry have been developed using dehydration reactions between oxyanions and carboxylic acids at the ES interface. Twelve oxyanions (VO 3 − , CrO 4 2− , MoO 4 2− , WO 4 2− , BO 3 3− , SiO 3 2− , SiO 4 4− , AsO 4 4− , AsO 2 − , SeO 4 2− , SeO 3 2− and NO 2 − ), out of 16 tested, reacted with at least one of four aminopolycarboxylic acids, i.e. iminodiacetic acid (IDA), nitrilotriacetic acid (NTA), trans ‐1,2‐diaminocyclohexane‐ N , N , N ′, N ′‐tetraacetic acid and triethylenetetramine‐ N , N , N ′, N ″, N ′″, N ′″‐hexaacetic acid, at the ES interface to produce the dehydration products that gave intense mass ion responses, sufficient for trace analysis. As examples, trace determinations of Cr VI and silica in water samples were achieved after online ion exchange chromatography, where the dehydration product of CrO 4 2− and NTA ( m / z 290) and that of SiO 4 4− and IDA ( m / z 192) were measured. The limits of detection of the respective methods were 17 nM (0.83 ng Cr/ml) for Cr VI and 0.17 μM (4.8 ng Si/mL) for SiO 4 4− . Copyright © 2016 John Wiley & Sons, Ltd.