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Laser desorption ionization of small molecules assisted by tungsten oxide and rhenium oxide particles
Author(s) -
Bernier Matthew C.,
Wysocki Vicki H.,
Dagan Shai
Publication year - 2015
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.3597
Subject(s) - chemistry , desorption , inorganic chemistry , molecule , analyte , mass spectrometry , rhenium , protonation , ionization , matrix assisted laser desorption/ionization , tungsten , analytical chemistry (journal) , photochemistry , oxide , ion , organic chemistry , chromatography , adsorption
Inorganic metal oxides have shown potential as matrices for assisting in laser desorption ionization with advantages over the aromatic acids typically used. Rhenium and tungsten oxides are attractive options due to their high work functions and relative chemical inertness. In this work, it is shown that ReO 3 and WO 3 , in microparticle (μP) powder forms, can efficiently facilitate ionization of various types of small molecules and provide minimized background contamination at analyte concentrations below 1 ng/µL. This study shows that untreated inorganic WO 3 and ReO 3 particles are valid matrix options for detection of protonatable, radical, and precharged species under laser desorption ionization. Qualitatively, the WO 3 μP showed improved detection of apigenin, sodiated glucose, and precharged analyte choline, while the ReO 3 μP allowed better detection of protonated cocaine, quinuclidine, ametryn, and radical ions of polyaromatic hydrocarbons at detection levels as low as 50 pg/µL. For thermometer ion survival yield experiments, it was also shown that the ReO 3 powder was significantly softer than α ‐cyano‐4‐hydroxycinnaminic acid. Furthermore, it provided higher intensities of cocaine and polyaromatic hydrocarbons, at laser flux values equal to those used with α ‐cyano‐4‐hydroxycinnaminic acid. Copyright © 2015 John Wiley & Sons, Ltd.