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A comprehensive library‐based, automated screening procedure for 46 synthetic cannabinoids in serum employing liquid chromatography‐quadrupole ion trap mass spectrometry with high‐temperature electrospray ionization
Author(s) -
Huppertz L. M.,
Kneisel S.,
Auwärter V.,
Kempf J.
Publication year - 2014
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.3267
Subject(s) - synthetic cannabinoids , chemistry , forensic toxicology , electrospray ionization , ion trap , drugs of abuse , mass spectrometry , chromatography , quadrupole ion trap , immunoassay , antibody , psychiatry , cannabinoid , drug , psychology , biochemistry , receptor , immunology , biology
Immunoassay for screening of drugs of abuse is probably the most often used method in clinical and forensic toxicology. However, the huge structural variety of synthetic cannabinoids seriously challenges tests on the basis of antibodies. The authors here describe a very rapid and highly sensitive approach based on MS and MS/MS data combined with library search, which is not only precise and robust, but even meets the criteria for forensic guidelines, an important precondition. Since the variability of the ‘Legal High’ products is high ‐ new compounds need to be added to the list very often ‐ this approach can easily and rapidly be adapted to new situations. The analytical toxicology group from the Medical Center of the University of Freiburg has a record for the development of innovative and powerful strategies for the determination of drugs of abuse.