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Comparison of the sensitivity of mass spectrometry atmospheric pressure ionization techniques in the analysis of porphyrinoids
Author(s) -
Świder Paweł,
Lewtak Jan P.,
Gryko Daniel T.,
Danikiewicz Witold
Publication year - 2013
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.3261
Subject(s) - chemistry , photoionization , mass spectrometry , ionization , direct electron ionization liquid chromatography–mass spectrometry interface , atmospheric pressure chemical ionization , electrospray ionization , analytical chemistry (journal) , chemical ionization , atmospheric pressure , ambient ionization , extractive electrospray ionization , chromatography , ion , sample preparation in mass spectrometry , organic chemistry , oceanography , geology
The porphyrinoids chemistry is greatly dependent on the data obtained in mass spectrometry. For this reason, it is essential to determine the range of applicability of mass spectrometry ionization methods. In this study, the sensitivity of three different atmospheric pressure ionization techniques, electrospray ionization, atmospheric pressure chemical ionization and atmospheric pressure photoionization, was tested for several porphyrinods and their metallocomplexes. Electrospray ionization method was shown to be the best ionization technique because of its high sensitivity for derivatives of cyanocobalamin, free‐base corroles and porphyrins. In the case of metallocorroles and metalloporphyrins, atmospheric pressure photoionization with dopant proved to be the most sensitive ionization method. It was also shown that for relatively acidic compounds, particularly for corroles, the negative ion mode provides better sensitivity than the positive ion mode. The results supply a lot of relevant information on the methodology of porphyrinoids analysis carried out by mass spectrometry. The information can be useful in designing future MS or liquid chromatography–MS experiments. Copyright © 2013 John Wiley & Sons, Ltd.