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Baseline resolution of isomers by traveling wave ion mobility mass spectrometry: investigating the eff ects of polarizable drift gases and ionic charge distribution
Author(s) -
Lalli Priscila M.,
Corilo Yuri E.,
Fasciotti Maíra,
Riccio Maria Francesca,
Sá Gilberto Fernandes,
Daroda Romeu J.,
Souza Gustavo H. M. F.,
McCullagh Michael,
Bartberger Michael D.,
Eberlin Marcos N.,
Campuzano Iain
Publication year - 2013
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.3192
Subject(s) - polarizability , chemistry , ion mobility spectrometry , ion , dipole , ionic bonding , analytical chemistry (journal) , mass spectrometry , molecule , chemical physics , atomic physics , molecular physics , chromatography , physics , organic chemistry
Coupling ion mobility (IM) with MS offers a potential solution for resolving structural isomers. Ion mobility separates ions according to size and shape because they interact differently with the neutral drift‐gas molecules. However, the majority of routine IM‐MS measurements rely on drift‐gases with low polarizability such as He and N2. In the Special Feature Lalli et al. investigate polarizable molecules as drift‐gas to determine if the dipolar ion‐neutral interactions enhance ion mobility separations of shape‐similar analytes. Their results suggest that the polarizability of the drift‐gas and the distribution of charge on the ion influence the degree of IM separation.