Premium
High mass resolution breath analysis using secondary electrospray ionization mass spectrometry assisted by an ion funnel
Author(s) -
Meier Lukas,
Berchtold Christian,
Schmid Stefan,
Zenobi Renato
Publication year - 2012
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.3118
Subject(s) - chemistry , mass spectrometry , fourier transform ion cyclotron resonance , analytical chemistry (journal) , electrospray ionization , resolution (logic) , electrospray , ion trap , ion , extractive electrospray ionization , ionization , ambient ionization , chromatography , desorption electrospray ionization , sample preparation in mass spectrometry , chemical ionization , organic chemistry , artificial intelligence , computer science
In this study, we used secondary electrospray ionization mass spectrometry assisted by an ion funnel (IF) operating at ambient pressure to find compounds in the mass range of 100–500 m/z in online breath fingerprinting experiments. In low‐resolution experiments conducted on an ion trap instrument, we found that pyridine is present in breath of individuals long after drinking coffee. In high‐resolution experiments conducted on a Fourier transform ion cyclotron resonance, we found more than 30 compounds in the mass range of 100–500 m/z in analogous online breath experiments. More than a third of these compounds have molecular weights above 200 Daltons and have not been mentioned in previous studies. In low‐resolution experiments as well as experiments without the IF, these compounds could not be detected. Copyright © 2012 John Wiley & Sons, Ltd.