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Gas‐flow assisted ion transfer for mass spectrometry
Author(s) -
Garimella Sandilya,
Xu Wei,
Huang Guangming,
Harper Jason D.,
Cooks R Graham,
Ouyang Zheng
Publication year - 2012
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.2955
Subject(s) - chemistry , laminar flow , mass spectrometry , ion , ionization , ambient ionization , ion source , analytical chemistry (journal) , chemical ionization , electrospray ionization , thermal ionization , desorption electrospray ionization , desorption , chromatography , mechanics , electron ionization , physics , adsorption , organic chemistry
Methods and devices that use gas flows to collect ions and transfer them over long distances for mass spectrometric analysis have been developed. Gas flows derived from the ionization source itself or provided by means of additional pumping were used to generate a laminar flow inside cylindrical tube. Hydrodynamic simulations and experimental tests demonstrate that laminar flow can transfer ions over long distance. The typical angular discrimination effects encountered when sampling ions from ambient ionization sources are minimized, and the sampling of relatively large surface areas is demonstrated with desorption electrospray ionization (DESI). Ion transfer over 6 m has been achieved and its application to multiplexed chemical analysis is demonstrated on samples at locations remote from the mass spectrometer. Copyright © 2012 John Wiley & Sons, Ltd.