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Mass spectrometric studies of 2‐aryl‐5‐acetylthiazole derivatives
Author(s) -
Giorgi Gianluca,
Salvini Laura,
Attanasi Orazio A.,
Guidi Barbara,
Santeusanio Stefania
Publication year - 2002
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.269
Subject(s) - chemistry , aryl , mass spectrometry , organic chemistry , combinatorial chemistry , chromatography , alkyl
Electron ionisation mass spectrometry was usefully used to characterize structurally 2‐aryl‐5‐acetylthiazole derivatives in the gas phase. The compounds show characteristic fragmentation pathways depending on the chemical nature of the substituent at position 2, consisting mainly in the cleavage of both the 1,2‐ and 3,4‐bonds of the thiazole ring. Liquid secondary ion mass spectrometry was applied to study the effects of protonation on the gas‐phase unimolecular reactions of this class of compound. Tandem mass spectrometric experiments, carried out on molecular and protonated molecular ions, and also on fragment ions produced in the source, allowed the elucidation of gas‐phase decompositions of low‐internal energy ions. Copyright © 2001 John Wiley & Sons, Ltd.