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Electrospray tandem mass spectrometric study of alkyl 1‐methylpyridinium ether derivatives of alcohols
Author(s) -
Quirke J. Martin E.,
Van Berkel Gary J.
Publication year - 2001
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.233
Subject(s) - chemistry , fragmentation (computing) , alkyl , alcohol , ether , tandem mass spectrometry , electrospray , mass spectrometry , ion , mass spectrum , tandem , medicinal chemistry , primary alcohol , organic chemistry , chromatography , catalysis , materials science , computer science , composite material , operating system
The fragmentation of 15 alkyl 1‐methylpyridinium ether derivatives (D + ) of primary and secondary alcohols, benzylic alcohols and phenyl‐substituted alcohols was investigated using energy‐resolved tandem mass spectrometry. Fragmentation pathways and mechanisms, including the influence of substituents, on the formation of the major product ions, which appear at m / z 110, [D − 109] + and [D − 111] + , were postulated. Comparison of the abundances of these ions in the product ion spectra of isomeric alcohol derivatives, obtained at the same center‐of‐mass collision energy (2.0 eV), was found to provide the ability to differentiate among some isomers. Copyright © 2001 John Wiley & Sons, Ltd.