Cyclic peptide as reference system for b ion structural analysis in the gas phase | Zendy

Chen Xian | Zendy; Tirado Marcus | Zendy; Steill Jeffrey D. | Zendy; Oomens Jos | Zendy; Polfer Nick C. | Zendy

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Cyclic peptide as reference system for b ion structural analysis in the gas phase

Author(s) -

Chen Xian,

Tirado Marcus,

Steill Jeffrey D.,

Oomens Jos,

Polfer Nick C.

Publication year - 2011

Publication title -

journal of mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 1076-5174

DOI - 10.1002/jms.1982

Subject(s) - chemistry , hydrogen–deuterium exchange , peptide , deuterium , dissociation (chemistry) , hydrogen , cyclic peptide , infrared multiphoton dissociation , stereochemistry , gas phase , acetylation , residue (chemistry) , ion , crystallography , organic chemistry , biochemistry , physics , quantum mechanics , gene

Infrared multiple photon dissociation spectroscopy and hydrogen/deuterium exchange methods are used to confirm the macrocylic structure of a b 6 peptide fragment by direct comparison with a synthetically made cyclic peptide. The acetylation of the peptide N‐terminus results in the inhibition of the macrocyclic formation, supporting the “head‐to‐tail” cyclization mechanism. Differences in hydrogen/deuterium exchange rates for macrocyclic and oxazalone structure peptide fragments are interpreted to be a result of the complex interplay of multiple basic sites in the peptide fragment, supporting the relay mechanism for deuterium exchange with CH 3 OD. Copyright © 2011 John Wiley & Sons, Ltd.

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