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MALDI‐TOFMS analysis of coordination and organometallic complexes: a nic(h)e area to work in
Author(s) -
Wyatt Mark F.
Publication year - 2011
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.1957
Subject(s) - chemistry , group 2 organometallic chemistry , coordination complex , combinatorial chemistry , organic chemistry , molecule , metal
A mini‐review of the characterisation of metal‐containing compounds by matrix‐assisted laser desorption/ionisation time‐of‐flight mass spectrometry (MALDI‐TOFMS) is presented. Organometallic and coordination compounds have many varied applications, most notably in industrial catalytic processes and also in the electronics and healthcare sectors. In general, the compounds discussed, be they small or large molecules, have a high percentage metal content, rather than simply containing ‘a metal atom’. A brief history of the field is given, but the main scope over the last 5 years is covered in some detail. How MALDI‐TOFMS compliments electrospray for metal‐containing compounds is highlighted. Perspectives on recent advances, such as solvent‐free and air/moisture‐sensitive sample preparation, and potential future challenges and developments, such as nanomaterials and metallodrug/metallometabolite imaging, are given. Copyright © 2011 John Wiley & Sons, Ltd.

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