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High spatial resolution imaging mass spectrometry and classical histology on a single tissue section
Author(s) -
Deutskens Fabian,
Yang Junhai,
Caprioli Richard M.
Publication year - 2011
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.1926
Subject(s) - chemistry , mass spectrometry imaging , mass spectrometry , high resolution , histology , section (typography) , maldi imaging , chromatography , pathology , matrix assisted laser desorption/ionization , remote sensing , organic chemistry , medicine , adsorption , desorption , advertising , business , geology
The work presented in this report describes and demonstrates a protocol for protein imaging analysis of biological tissue using MALDI IMS where histological staining and MS analysis are performed on the same tissue section. Spatial image resolution is shown at 35 µm for sagittal sections of the cerebellum from rat brain. Copyright © 2011 John Wiley & Sons, Ltd.