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Ionic liquid‐assisted electrospray ionization of polysaccharides
Author(s) -
Chang YuLing,
Lee YuanChun,
Yang WenBin,
Chen ChungHsuan
Publication year - 2011
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.1902
Subject(s) - chemistry , ionic liquid , electrospray ionization , electrospray , mass spectrometry , ion , polysaccharide , mass spectrum , protonation , analytical chemistry (journal) , ionization , ionic bonding , chromatography , organic chemistry , catalysis
In this work, we give the report of significant detection sensitivity improvement of electrospray ionization (ESI) mass spectra of polysaccharides by adding various ionic liquid compounds into samples. Mass spectra obtained were greatly simplified and appeared to be similar to spectra from matrix‐assisted laser desorption/ionization due to the narrow charge number distribution. Mass spectra of polysaccharides with the attachment of either anion or cation of ionic liquid compounds were observed. No protonated or deprotonated polysaccharide ions were detected when ionic liquid compounds were added into samples. Little alkali‐attached polysaccharide ions were observed. Ionic liquid‐assisted ESI (ILA‐ESI) mass spectrometry has significantly improved the detection sensitivity of large neutral polysaccharide compounds. Copyright © 2011 John Wiley & Sons, Ltd.