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Effects of transition metal ion coordination on the collision‐induced dissociation of polyalanines
Author(s) -
Watson Heather M.,
Vincent John B.,
Cassady Carolyn J.
Publication year - 2011
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.1839
Subject(s) - chemistry , collision induced dissociation , transition metal , dissociation (chemistry) , ion , collision , coordination complex , metal , inorganic chemistry , mass spectrometry , organic chemistry , tandem mass spectrometry , catalysis , chromatography , computer science , computer security
One of the challenges for sequencing peptides by MS‐MS is the interpretation of complex fragment ion patterns. Many approaches have been explored seeking to produce fragmentation patterns that are more predictable and thus easier to interpret. One of these involves the formation of a gas‐phase adduct of peptide with a metal ion which acts to preferentially activate certain fragmentation pathways. In this month's Special Feature, Prof. Carolyn Cassady and co‐workers at the University of Alabama (Tuscaloosa, AL) examine the fragmentation patterns produced from first‐row transition metal adducts of some model peptides with the goal of gaining insight into the gas‐phase chemistry of transition metal‐cationized peptides and to increase the understanding of how specific transition metal ions affect dissociation of the peptide backbone.