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Fully automated liquid extraction‐based surface sampling and ionization using a chip‐based robotic nanoelectrospray platform
Author(s) -
Kertesz Vilmos,
Van Berkel Gary J.
Publication year - 2010
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.1709
Subject(s) - chemistry , sampling (signal processing) , chip , chromatography , software , extraction (chemistry) , interface (matter) , surface (topology) , sample preparation , analytical chemistry (journal) , sample (material) , ionization , computer hardware , computer science , computer vision , engineering , electrical engineering , ion , gibbs isotherm , geometry , mathematics , organic chemistry , filter (signal processing) , adsorption , programming language
A fully automated liquid extraction‐based surface sampling device utilizing an Advion NanoMate chip‐based infusion nanoelectrospray ionization system is reported. Analyses were enabled for discrete spot sampling by using the Advanced User Interface of the current commercial control software. This software interface provided the parameter control necessary for the NanoMate robotic pipettor to both form and withdraw a liquid microjunction for sampling from a surface. The system was tested with three types of analytically important sample surface types, viz ., spotted sample arrays on a MALDI plate, dried blood spots on paper, and whole‐body thin tissue sections from drug dosed mice. The qualitative and quantitative data were consistent with previous studies employing other liquid extraction‐based surface sampling techniques. Published in 2009 by John Wiley & Sons, Ltd.