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Mass spectrometry of selective androgen receptor modulators
Author(s) -
Thevis Mario,
Schänzer Wilhelm
Publication year - 2008
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.1438
Subject(s) - chemistry , electrospray ionization , androgen receptor , anabolic agents , virtual screening , drug discovery , anabolism , mass spectrometry , combinatorial chemistry , computational biology , pharmacology , biochemistry , chromatography , medicine , cancer , prostate cancer , biology
Nonsteroidal selective androgen receptor modulators (SARMs) are an emerging class of drugs for treatment of various diseases including osteoporosis and muscle wasting as well as the correction of age‐related functional decline such as muscle strength and power. Several SARMs, which have advanced to preclinical and clinical trials, are composed of diverse chemical structures including arylpropionamide‐, bicyclic hydantoin‐, quinoline‐, and tetrahydroquinoline‐derived nuclei. Since January 2008, SARMs have been categorized as anabolic agents and prohibited by the World Anti‐Doping Agency (WADA). Suitable detection methods for these low‐molecular weight drugs were based on mass spectrometric approaches, which necessitated the elucidation of dissociation pathways in order to characterize and identify the target analytes in doping control samples as well as potential metabolic products and synthetic analogs. Fragmentation patterns of representatives of each category of SARMs after electrospray ionization (ESI) and collision‐induced dissociation (CID) as well as electron ionization (EI) are summarized. The complexity and structural heterogeneity of these drugs is a daunting challenge for detection methods. Copyright © 2008 John Wiley & Sons, Ltd.