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High‐throughput mass spectrometry: the mechanism of sudan azo dye fragmentation by ESI tandem mass spectrometry and extensive deuterium labeling experiments
Author(s) -
Di Donna Leonardo,
De Nino Antonio,
Maiuolo Loredana,
Mazzotti Fabio,
Napoli Anna,
Salerno Raffaele,
Sindona Giovanni
Publication year - 2007
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.1236
Subject(s) - chemistry , deuterium , mass spectrometry , fragmentation (computing) , tandem mass spectrometry , isotope dilution , protonation , molecule , chromatography , organic chemistry , ion , physics , quantum mechanics , computer science , operating system
The investigation of the gas‐phase chemistry of azo compounds by mass spectrometry dates back to the introduction of this peculiar research field into the armory of physical organic chemistry tools. The mechanism of the fragmentation of the azo double bond from the protonated precursor is discussed with reference to the behavior of deuterium‐labeled reference compounds. The investigated molecules belong to the sudan family and the results can be used for the detection of these potential carcinogenic compounds in different matrices by means of the isotope dilution method. Copyright © 2007 John Wiley & Sons, Ltd.