Premium
Investigation of doubly charged organic cations by electrospray ion cyclotron resonance mass spectrometry
Author(s) -
Katritzky Alan R.,
Shipkova Petia A.,
Burton Richard D.,
Allin Steven M.,
Watson Clifford H.,
Eyler John R.
Publication year - 1995
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.1190301110
Subject(s) - chemistry , fourier transform ion cyclotron resonance , mass spectrometry , electrospray ionization , electrospray , ion cyclotron resonance , tandem mass spectrometry , analytical chemistry (journal) , dissociation (chemistry) , ion , top down proteomics , pyridinium , collision induced dissociation , selected reaction monitoring , ion source , chromatography , cyclotron , organic chemistry
The production and detection of doubly charged organic cations were studied using a previously unreported approach—electrospray ionization coupled with Fourier transform ion cyclotron resonance mass spectrometry. Owing to its ultra‐high mass resolution, accurate and stable mass calibration, multiple stages of collisionally activated dissociation (CAD) allowing tandem mass spectrometry and extremely long ion storage times (> 1 min), this technique has proven to be a powerful method for the detection and study of doubly charged organic compounds. CAD studies were used for the identification of ion–molecule reactions and for the investigation of the propensity towards gas‐phase S N 1 and S N 2 reaction pathways. To date exclusively S N 1‐type reactions in the gas phase have been detected. Three doubly charged pyridinium salts were chosen as model compounds for this study.