Identification and determination of cystathionine sulfoxide and NAc‐cystathionine sulfoxide in the urine of a patient with cystathioninuria using liquid chromatography/atmospheric pressure chemical ionization mass spectrometry | Zendy

Zhang Jianying | Zendy; Masuoka Noriyoshi | Zendy; Ubuka Toshihiko | Zendy; Kodama Hiroyuki | Zendy

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Identification and determination of cystathionine sulfoxide and NAc‐cystathionine sulfoxide in the urine of a patient with cystathioninuria using liquid chromatography/atmospheric pressure chemical ionization mass spectrometry

Author(s) -

Zhang Jianying,

Masuoka Noriyoshi,

Ubuka Toshihiko,

Kodama Hiroyuki

Publication year - 1995

Publication title -

journal of mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 1076-5174

DOI - 10.1002/jms.1190300914

Subject(s) - cystathionine beta synthase , chemistry , sulfoxide , methionine sulfoxide , urine , chromatography , mass spectrometry , homocystinuria , metabolite , biochemistry , methionine , organic chemistry , amino acid

Novel cystathionine metabolities, cystathionine sulfoxide and NAc‐cystathionine sulfoxide, were identified in the urine of a patient with cystathioninuria using liquid chromatography/mass spectrometry with an atmospheric pressure chemical ionization interface system. NAc‐cystathionine sulfoxide was discovered as a new metabolite of cystathionine in the urine of a cystathioninuric patient. The concentrations of cystathionine sulfoxide and NAc‐cystathionine sulfoxide in this urine were also determined for the first time using this method, and were 28.69 ± 0.44 and 10.51 ± 0.49 mg g −1 creatinine, respectively. Neither compound was detected in the urine of healthy subjects.

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