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Identification and determination of cystathionine sulfoxide and NAc‐cystathionine sulfoxide in the urine of a patient with cystathioninuria using liquid chromatography/atmospheric pressure chemical ionization mass spectrometry
Author(s) -
Zhang Jianying,
Masuoka Noriyoshi,
Ubuka Toshihiko,
Kodama Hiroyuki
Publication year - 1995
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.1190300914
Subject(s) - cystathionine beta synthase , chemistry , sulfoxide , methionine sulfoxide , urine , chromatography , mass spectrometry , homocystinuria , metabolite , biochemistry , methionine , organic chemistry , amino acid
Novel cystathionine metabolities, cystathionine sulfoxide and NAc‐cystathionine sulfoxide, were identified in the urine of a patient with cystathioninuria using liquid chromatography/mass spectrometry with an atmospheric pressure chemical ionization interface system. NAc‐cystathionine sulfoxide was discovered as a new metabolite of cystathionine in the urine of a cystathioninuric patient. The concentrations of cystathionine sulfoxide and NAc‐cystathionine sulfoxide in this urine were also determined for the first time using this method, and were 28.69 ± 0.44 and 10.51 ± 0.49 mg g −1 creatinine, respectively. Neither compound was detected in the urine of healthy subjects.