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Negative‐ion fast atom bombardment tandem mass spectrometry of sodium salts of monensins and related compounds
Author(s) -
Havlíček Vladimír,
Ryska Miroslav,
Pospíšil Stanislav
Publication year - 1995
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.1190300805
Subject(s) - chemistry , fast atom bombardment , ion , mass spectrum , alkali metal , sodium , mass spectrometry , dissociation (chemistry) , tandem mass spectrometry , substituent , collision induced dissociation , analytical chemistry (journal) , inorganic chemistry , stereochemistry , organic chemistry , chromatography
The negative‐ion collisionally induced dissociation fast atom bombardment mass spectra of sodium salts of monensins A and B, their 3‐ O ‐demethyl derivatives, laidlomycin and 26‐deoxylaidlomycin are reported. The nature of the R 3 substituent appears to be important for the formation of sodium‐containing product ions. Fragment ion series observed in the mass spectra of the [M − H] − ions of monensins are characterized by alkali metal retention. In contrast to monensins, the product ions observed in the corresponding spectra of laidlomycins are sodium free. The affinity of monensins to alkali metals is a useful feature that may be used for the structure determination of unknown monensins, their metabolites and derivates. The structure of a novel natural monensin was elucidated based on its mass spectrometric behaviour.