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Alkali metal cationization and its effect on the collision‐induced decomposition of taxol
Author(s) -
Madhusudanan K. P.
Publication year - 1995
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.1190300508
Subject(s) - chemistry , side chain , decomposition , alkali metal , lithium (medication) , ring (chemistry) , taxane , ion , metal , lithium metal , medicinal chemistry , stereochemistry , organic chemistry , medicine , electrode , cancer , breast cancer , electrolyte , endocrinology , polymer
The effect of alkali metal cationization on the collision‐induced decomposition of taxol is discussed. The facile elimination of H 2 O observed from the [M + H] + ion does not occur from the corresponding [M + Met] + ion. Some of the major decomposition pathways appear to be charge‐remote fragmentations involving eliminations of the functional groups on the taxane ring or the cleavage of the side‐chain with retention of the metal ion on either the side‐chain or the taxane ring. The collision‐induced decompositions of the lithiated side‐chain reflect multi‐site binding of the lithium ion with the basic centres in the side‐chain.