Massive cluster impact ionization on a four sector tandem mass spectrometer | Zendy

Fabris D. | Zendy; Wu Z. | Zendy; Fenselau C. C. | Zendy

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Massive cluster impact ionization on a four sector tandem mass spectrometer

Author(s) -

Fabris D.,

Wu Z.,

Fenselau C. C.

Publication year - 1995

Publication title -

journal of mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 1076-5174

DOI - 10.1002/jms.1190300121

Subject(s) - chemistry , tandem , tandem mass spectrometry , ion , covalent bond , oligonucleotide , mass spectrometry , molecule , cluster (spacecraft) , ionization , analytical chemistry (journal) , chromatography , dna , organic chemistry , biochemistry , materials science , computer science , composite material , programming language

High energy gycerol cluster ions from an electrohydrodynamic ion gun have been used as a primary ion beam to generate secondary ions of proteins with molecular weights up to 29 kDa and oligonucleotides. The technique not only demonstrated good performance in the picomole/nanomole range for the desorbtion of highly polar and fragile molecules such as proteins and deoxyoligonucleotides, but it also allowed the observation of a non‐covalent complex in the form of a deoxyoligonucleotide duplex. We have also shown that it is feasible to carry out structural analysis of oligonucleotides by collisional activation in a four sector tandem instrument.

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