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Inter‐laboratory comparison of elemental analysis and gas chromatography combustion isotope ratio mass spectrometry (GC‐C‐IRMS). Part I: δ 13 C measurements of selected compounds for the development of an isotopic Grob‐test
Author(s) -
Serra F.,
Janeiro A.,
Calderone G.,
Rojas J. M. Moreno,
Rhodes C.,
Gonthier L. A.,
Martin F.,
Lees M.,
Mosandl A.,
Sewenig S.,
Hener U.,
Henriques B.,
Ramalho L.,
Reniero F.,
Teixeira A. J.,
Guillou C.
Publication year - 2007
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.1168
Subject(s) - chemistry , isotope ratio mass spectrometry , mass spectrometry , gas chromatography , chromatography , combustion , analytical chemistry (journal) , stable isotope ratio , certified reference materials , reproducibility , calibration , organic chemistry , detection limit , statistics , mathematics , quantum mechanics , physics
This study was directed towards investigating suitable compounds to be used as stable isotope reference materials for gas chromatography combustion isotope ratio mass spectrometry (GC‐C‐IRMS) calibration. Several compounds were selected from those used in the ‘Grob‐test’ mixture. Oxygen‐ and nitrogen‐containing substances were added to these compounds to allow the mixture to be used as a possible multi‐isotopic calibration tool for 2 H/ 1 H, 13 C/ 12 C, 15 N/ 14 N and 18 O/ 16 O ratio determinations. In this paper we present the results of δ 13 C measurements performed by the consortium of the five laboratories taking part in this inter‐calibration exercise. All the compounds were individually assessed for homogeneity, short‐term stability and long‐term stability by means of EA‐IRMS, as required by the bureau communitaire de reference (BCR) Guide for Production of Certified Reference Materials. The results were compared then with the GC‐C‐IRMS measurements using both polar and non‐polar columns, and the final mixture of selected compounds underwent a further certification exercise assessing limits of accuracy and reproducibility under specified GC‐C‐IRMS conditions. Copyright © 2007 John Wiley & Sons, Ltd.