The metabolism of norethandrolone in the horse: characterization of 16‐, 20‐ and 21‐oxygenated metabolites by gas chromatography/mass spectrometry | Zendy

McKinney Andrew R. | Zendy; Ridley Damon D. | Zendy; Suann Craig J. | Zendy

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The metabolism of norethandrolone in the horse: characterization of 16‐, 20‐ and 21‐oxygenated metabolites by gas chromatography/mass spectrometry

Author(s) -

McKinney Andrew R.,

Ridley Damon D.,

Suann Craig J.

Publication year - 2001

Publication title -

journal of mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 1076-5174

DOI - 10.1002/jms.111

Subject(s) - chemistry , chromatography , trimethylsilyl , mass spectrometry , urine , metabolite , gas chromatography–mass spectrometry , metabolism , gas chromatography , horse , anabolic steroid , anabolism , biochemistry , organic chemistry , paleontology , biology

After oral administration to a thoroughbred gelding, the anabolic steroid norethandrolone was converted into a complex mixture of oxygenated metabolites. These metabolites were extracted from the urine, deconjugated by methanolysis and converted to their O ‐methyloxime trimethylsilyl derivatives. Gas chromatographic/mass spectrometric analysis indicated the major metabolites to be 19‐norpregnane‐3,16,17‐triols, 19‐norpregnane‐3,17,20‐triols and 3,17‐dihydroxy‐19‐norpregnan‐21‐oic acids. Some minor metabolites were also detected. Copyright © 2001 John Wiley & Sons, Ltd.

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