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DNA analysis by mass spectrometry—past, present and future
Author(s) -
Tost Jörg,
Gut Ivo Glynne
Publication year - 2006
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/jms.1096
Subject(s) - chemistry , nucleic acid , deoxyribose , dna , rna , dna methylation , computational biology , mass spectrometry , nucleic acid quantitation , biochemistry , chromatography , gene expression , gene , biology
Abstract The analysis of deoxyribose nucleic acid (DNA) by mass spectrometry (MS) has evolved to where it can be used to analyze most known types of DNA and ribose nucleic acid (RNA) situations. It can efficiently deal with the analysis of DNA polymorphisms, sequences, haplotypes, human leukocyte antigen (HLA) typing, DNA methylation and RNA expression. Implementations of MS for these forms of DNA analyses are reviewed. The use of DNA analysis by MS is compared with competing technologies. Finally, an overview is given of worthwhile applications where the know‐how gained so far could be used for future developments. Copyright © 2006 John Wiley & Sons, Ltd.