Premium
Feasibility of Intestinal MR Elastography in Inflammatory Bowel Disease
Author(s) -
Reiter Rolf,
Loch Florian N.,
Kamphues Carsten,
Bayerl Christian,
Marticorena Garcia Stephan R.,
Siegmund Britta,
Kühl Anja A.,
Hamm Bernd,
Braun Jürgen,
Sack Ingolf,
Asbach Patrick
Publication year - 2022
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.27833
Subject(s) - medicine , ulcerative colitis , inflammatory bowel disease , elastography , receiver operating characteristic , confidence interval , prospective cohort study , gastroenterology , radiology , ultrasound , disease
Background While MR enterography allows detection of inflammatory bowel disease (IBD), the findings continue to be of limited use in guiding treatment—medication vs. surgery. Purpose To test the feasibility of MR elastography of the gut in healthy volunteers and IBD patients. Study Type Prospective pilot. Population Forty subjects (healthy volunteers: n = 20, 37 ± 14 years, 10 women; IBD patients: n = 20 (ulcerative colitis n = 9, Crohn's disease n = 11), 41 ± 15 years, 11 women). Field Strength/Sequence Multifrequency MR elastography using a single‐shot spin‐echo echo planar imaging sequence at 1.5 T with drive frequencies of 40, 50, 60, and 70 Hz. Assessment Maps of shear‐wave speed (SWS, in m/s) and loss angle ( φ , in rad), representing stiffness and solid–fluid behavior, respectively, were generated using tomoelastography data processing. Histopathological analysis of surgical specimens was used as reference standard in patients. Statistical Tests Unpaired t‐test, one‐way analysis of variance followed by Tukey post hoc analysis, Pearson's correlation coefficient and area under the receiver operating characteristic curve (AUC) with 95%‐confidence interval (CI). Significance level of 5%. Results MR elastography was feasible in all 40 subjects (100% technical success rate). SWS and φ were significantly increased in IBD by 21% and 20% (IBD: 1.45 ± 0.14 m/s and 0.78 ± 0.12 rad; healthy volunteers: 1.20 ± 0.14 m/s and 0.65 ± 0.06 rad), whereas no significant differences were found between ulcerative colitis and Crohn's disease ( P = 0.74 and 0.90, respectively). In a preliminary assessment, a high diagnostic accuracy in detecting IBD was suggested by an AUC of 0.90 (CI: 0.81–0.96) for SWS and 0.84 (CI: 0.71–0.95) for φ . Data Conclusion In this pilot study, our results demonstrated the feasibility of MR elastography of the gut and showed an excellent diagnostic performance in predicting IBD. Evidence Level 1 Technical Efficacy Stage 1