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Myocardial Deformation Assessed by MR Feature Tracking in Groups of Patients With Ischemic Heart Disease
Author(s) -
Zhao Lei,
Zhang Chen,
Tian Jie,
DeLano Mark,
Ma Xiaohai
Publication year - 2021
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.27588
Subject(s) - medicine , coronary artery disease , cardiology , myocardial infarction , contractility , perfusion , magnetic resonance imaging , ischemia , infarction , population , radiology , environmental health
Background Global myocardial strain assessments have been shown to provide useful measures of contractility in many diseases, but whether feature tracking (FT)‐derived strain at rest can differentiate ischemic myocardium from infarcted and remote myocardium in patients with coronary artery disease (CAD) remains unclear. Purpose To evaluate the performance of magnetic resonance imaging FT‐derived strain in the detection of regional myocardial deformation in ischemic, infarcted, and apparent normal myocardium in CAD. Study Type Retrospective Population A total of 109 patients with CAD. Field Strength/Sequences Steady‐state free‐precession rest cine, T1‐weighted saturation‐recovery fast gradient echo stress/rest perfusion, and two‐dimensional phase‐sensitive inversion recovery breath‐hold late gadolinium enhancement (LGE) tests were performed at 3.0 T. Assessment Based on perfusion and LGE images, left ventricular (LV) myocardial segments of CAD patients were categorized into ischemic, infarcted, and negative groups. The FT longitudinal (LS) and circumferential strain (CS) of normal subjects and the three CAD groups were calculated. Z‐scores of each segment of CAD patients were calculated. Statistic Tests χ 2 testing, analysis of variance (ANOVA), and Kruskal‐Wallis tests. Z‐scores were used to compare the strain between CAD groups. Results There were significant differences in global LS (GLS) and CS (GCS) between healthy controls (GLS: −19.0% ± 1.4%, GCS, −20.9% ± 1.8%), ischemia (GLS: −17.4% ± 2.1%, GCS, −19.6% ± 1.9%), infarction (GLS: −16.4% ± 1.9%, GCS, −17.8% ± 1.9%), and negative patients (GLS: −17.7% ± 1.4%, GCS, −20.9% ± 2.4%) (all P < 0.05). There were significant differences in regional LS and CS between ischemic (LS, −16.1% ± 5.0%, CS, −18.7% ± 5.0%), infarcted (LS, −14.8% ± 5.2%, CS, −15.3% ± 4.8%), and negative segments (LS, −17.6% ± 5.2%, CS, −19.8% ± 4.8%) (all P < 0.05). The differences in the z‐scores of regional LS and CS between the ischemic, infarcted, and negative segments were also significant (all P < 0.05). Data Conclusion FT‐derived rest strain indices of the LV myocardium of CAD patients were higher compared to healthy controls and varied between ischemic, infarcted, and negative segments. Level of Evidence 4 Technical Efficacy Stage 5.