Premium
Repeatability of dynamic 3D phase‐resolved functional lung (PREFUL) ventilation MR Imaging in patients with chronic obstructive pulmonary disease and healthy volunteers
Author(s) -
Klimeš Filip,
Voskrebenzev Andreas,
Gutberlet Marcel,
Obert Arnd J.,
Pöhler Gesa H.,
Grimm Robert,
Behrendt Lea,
Crisosto Cristian,
Glandorf Julian,
Moher Alsady Tawfik,
Wacker Frank,
VogelClaussen Jens
Publication year - 2021
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.27543
Subject(s) - repeatability , intraclass correlation , copd , medicine , interquartile range , ventilation (architecture) , vital capacity , coefficient of variation , lung volumes , nuclear medicine , prospective cohort study , lung , lung function , mathematics , diffusing capacity , statistics , engineering , psychometrics , mechanical engineering , clinical psychology
Background A previous study has demonstrated the feasibility of 3D phase‐resolved functional lung (PREFUL) MRI in healthy volunteers and patients with chronic pulmonary disease. Before clinical use, the repeatability of the ventilation parameters derived from 3D PREFUL MRI must be determined. Purpose To evaluate repeatability of 3D PREFUL and to compare with pulmonary functional lung testing (PFT). Study Type Prospective. Population Fifty‐three healthy subjects and 13 patients with chronic obstructive pulmonary disease (COPD). Field Strength/Sequence A prototype 3D stack‐of‐stars spoiled‐gradient‐echo sequence at 1.5 T. Assessment Study participants underwent repeated MRI examination (median time interval between scans COPD/healthy subjects [interquartile range]: 7/0 days [6–8/0–0 days]) and one PFT carried out at the time of the baseline MRI. For 3D PREFUL, regional ventilation (RVent) and flow‐volume loops were computed and rated by cross‐correlation (CC). Also, ventilation time‐to‐peak (VTTP) was computed. Ventilation defect percentage (VDP) maps were obtained for RVent and CC. Statistical Tests Repeatability of 3D PREFUL parameters was evaluated using Bland–Altman analysis, coefficient of variation (COV) and intraclass correlation coefficient (ICC). The relation between 3D PREFUL and PFT measures (forced expiratory volume in 1 second (FEV 1 ) and forced vital capacity (FVC) was assessed using the Pearson correlation coefficient ( r ). Results In healthy subjects and COPD patients, no significant bias (all P range: 0.09–0.77) and a moderate to good repeatability of RVent, VTTP, and VDP RVent were found (COV range: 0.1%–18.2%, ICC range: 0.51–0.88). For CC and VDP CC moderate repeatability was found (COV range: 0.6%–43.6%, ICC: 0.38–0.60). CC, VDP RVent , and VDP CC showed a good correlation with FEV 1 (all | r | > 0.58, all P < 0.05) and FEV 1 /FVC ratio (all | r | > 0.62, all P < 0.05). Data Conclusion 3D PREFUL provided a good repeatability of RVent, VTTP, and VDP RVent and moderate repeatability of CC and VDP CC in healthy volunteers and COPD patients, and correlated well with FEV 1 and FEV 1 /FVC. Level of Evidence 2 Technical Efficacy Stage 2