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Understanding Early Hemophilic Arthropathy in Children and Adolescents Through MRI T 2 Mapping
Author(s) -
Majeed Haris,
Ahmed Humayun,
Sussman Marshall S.,
Macgowan Christopher,
Rayner Tammy,
Weiss Ruth,
Feldman Brian M.,
Doria Andrea S.
Publication year - 2021
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.27406
Subject(s) - medicine , ankle , intraclass correlation , cartilage , tibia , arthropathy , magnetic resonance imaging , hemarthrosis , femur , nuclear medicine , analysis of variance , surgery , radiology , osteoarthritis , pathology , anatomy , clinical psychology , alternative medicine , psychometrics
Background Persons with hemophilia experience hemarthrosis, which can lead to cartilage degeneration, causing physical impairment. MRI T 2 mapping has the potential to be used as a tool to evaluate early arthropathic changes and cartilage degeneration in patients with hemophilia. Purpose To assess the value of MRI‐T 2 mapping as a tool for investigating the cartilage status of children and adolescents with hemophilic arthropathy. Study Type Prospective, cross‐sectional. Subjects Twenty‐eight boys with hemophilia (aged 5–17 years) and 23 healthy boys (aged 7–17 years). Field Strength/Sequences A multiecho spin‐echo T 2 ‐weighted gradient echo sequence was used on a 3.0T magnet. Assessment MRI‐T 2 maps of ankle (tibia‐talus) ( n = 19) or knee (femur‐tibia) ( n = 9) cartilage were assessed in hemophilia and healthy groups. An anatomically‐based MRI score was also assigned to each ankle/knee. Statistical Tests Pearson's correlation coefficient ( r ), linear regression, intraclass correlation coefficient (ICC), and analysis of variance (ANOVA) test. Results Negative associations between age and ankle/knee cartilage T 2 relaxation times were found in hemophilia ( r = –0.72 [ P = 0.03] to –0.55 [ P = 0.01]) and healthy ( r = –0.84 [ P < 0.001] to –0.55 [ P = 0.20]) groups. There were nonsignificant associations between ankle cartilage T 2 relaxation times and MRI scores ( r = –0.15 [ P = 0.54] to 0.31 [ P = 0.19]). Data Conclusion Results of this clinical investigation emphasize the potential importance of MRI‐T 2 maps as a tool to understand the functional status of cartilage in children and adolescents with hemophilic arthropathy, while holding promise for the detection of early cartilage degeneration prior to macroscopic characterization by conventional MRI. MRI‐T 2 mapping may provide novel information that is not reflected in the anatomically‐based MRI scoring system. Level of Evidence 3 Technical Efficacy Stage 2