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Ocular Blood Flow Measurements in Diabetic Retinopathy Using 3D Pseudocontinuous Arterial Spin Labeling
Author(s) -
Wang Huihui,
Sun Jiao,
Li Jing,
Li Hongyang,
Wang Yanling,
Wang Zhenchang
Publication year - 2021
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.27398
Subject(s) - medicine , intraclass correlation , diabetic retinopathy , receiver operating characteristic , blood flow , nuclear medicine , ophthalmology , diabetes mellitus , endocrinology , clinical psychology , psychometrics
Background Distinguishing between the two broad categories of diabetic retinopathy (DR), nonproliferative DR (NPDR) and proliferative DR (PDR), is significant, as the therapeutic strategies for each are completely different. Purpose To characterize the ocular blood flow (OBF) of DR patients and evaluate the potential utility of OBF values in categorizing DR. Study Type Prospective. Subjects A total of 41 DR patients (82 eyes) were recruited in our study. Group 1 comprised 48 eyes with NPDR, and Group 2 comprised 34 eyes with PDR. Field Strength/Sequence 3D pseudocontinuous arterial spin labeling (3D‐pcASL) with two postlabeling delays (PLDs) was acquired at 3.0T MR. Assessment OBF values were independently obtained by two doctors from the OBF map. Statistical Tests OBF values and clinical characteristics were compared between the groups using two‐sample t ‐tests and chi‐square tests. Receiver operating characteristic (ROC) curves were obtained, and the area under the curve (AUC) was calculated. The consistency of OBF values reported by the two doctors was evaluated using the intraclass correlation coefficient (ICC). Results OBF values at PLDs of 1.5 seconds and 2.5 seconds were significantly lower in Group 2 than in Group 1 ( P < 0.05 for both PLDs). The OBF values of Group 2 showed a greater increase than those of Group 1 from PLD 1.5 to 2.5 seconds. The AUC of OBF at the 1.5 seconds PLD was 0.90, with a cutoff of 7.73 mL/min/100 g, and the AUC of the OBF at the 2.5 seconds PLD was 0.75, with a cutoff of 8.44 mL/min/100 g. The ICC between the two observers was 0.844 for the OBF at 1.5 seconds PLD and 0.872 for the OBF at 2.5 seconds PLD. Data Conclusion PDR can be differentiated from NPDR by the value of OBF as measured by 3D‐pcASL. Level of Evidence 1 Technical Efficacy Stage 1