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In Vivo Proton Exchange Rate ( k ex ) MRI for the Characterization of Multiple Sclerosis Lesions in Patients
Author(s) -
Ye Haiqi,
Shaghaghi Mehran,
Chen Qianlan,
Zhang Yan,
Lutz Sarah E.,
Chen Weiwei,
Cai Kejia
Publication year - 2021
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.27363
Subject(s) - multiple sclerosis , white matter , medicine , nuclear medicine , magnetic resonance imaging , gadolinium , hyperintensity , pathology , lesion , radiology , chemistry , organic chemistry , psychiatry
Background Currently available radiological methods do not completely capture the diversity of multiple sclerosis (MS) lesion subtypes. This lack of information hampers the understanding of disease progression and potential treatment stratification. For example, inflammation persists in some lesions after gadolinium (Gd) enhancement resolves. Novel metabolic and molecular imaging methods may improve the current assessments of MS pathophysiology. Purpose To compare the in vivo proton exchange rate ( k ex ) MRI with Gd‐enhanced MRI for characterizing MS lesions. Study Type Retrospective. Subjects Sixteen consecutively diagnosed relapsing‐remitting multiple sclerosis (RRMS) patients. Field Strength/Sequence 3.0T MRI with T 2 ‐weighted imaging, postcontrast T 1 ‐weighted imaging, and single‐slice chemical exchange saturation transfer imaging. Assessment MS lesions in white matter were assessed for Gd enhancement and k ex elevation compared to normal‐appearing white matter (NAWM). Statistical Tests Student's t‐ test was used for analyzing the difference of k ex values between lesions and NAWM, with statistical significance set at 0.05. Results Of all 153 MS lesions, 78 (51%) lesions were Gd‐enhancing and 75 (49%) were Gd‐negative. Without exception, all 78 Gd‐enhancing lesions showed significantly elevated k ex values compared to NAWM (924 ± 130 s –1 vs. 735 ± 61 s –1 , P < 0.05). Of 75 Gd‐negative lesions, 18 lesions (24%) showed no k ex elevation (762 ± 29 s –1 vs. 755 ± 28 s –1 , P = 0.47) and 57 (76%) showed significant k ex elevation (950 ± 124 s –1 vs. 759 ± 48 s –1 , P < 0.05) compared to NAWM. MS lesions with k ex elevation appeared nodular (118, 87.4%), ring‐like (15, 11.1%), or irregular‐shaped (2, 1.5%). Data Conclusion For Gd‐enhancing lesions, k ex MRI is highly consistent with Gd‐enhanced images by showing 100% of elevated k ex . For all Gd‐negative lesions, the discrepancy on k ex MRI may further differentiate active slowly expanding lesions or chronic inactive lesions, supporting k ex as an imaging biomarker for tissue oxidative stress and inflammation. Level of Evidence 2 Technical Efficacy Stage 3 J. MAGN. RESON. IMAGING 2021;53:408–415.