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DTI Tract‐Based Quantitative Susceptibility Mapping: An Initial Feasibility Study to Investigate the Potential Role of Myelination in Brain Connectivity Change in Cerebral Palsy Patients During Autologous Cord Blood Cell Therapy Using a Rotationally‐Invariant Quantitative Measure
Author(s) -
Zhang Lijia,
Ellor Susan,
Sun Jessica M.,
Liu Chunlei,
Kurtzburg Joanne,
Song Allen W.
Publication year - 2021
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.27286
Subject(s) - medicine , corticospinal tract , quantitative susceptibility mapping , fractional anisotropy , diffusion mri , transcranial magnetic stimulation , magnetic resonance imaging , cerebral palsy , physical medicine and rehabilitation , radiology , stimulation
Background Previous studies using diffusion tensor imaging (DTI)‐based connectome analysis revealed improved connectivity in cerebral palsy (CP) patients who underwent autologous umbilical cord blood (UCB) stem‐cell therapy. However, the potential mechanism for the connectivity increase remains unclear and needs to be further elucidated. Purpose To develop a technique with improved accuracy for quantitative susceptibility mapping (QSM) with unique sensitivity to myelin, and demonstrate its use in elucidating the underlying mechanism of the observed motor function improvement and brain connectivity increase in CP patients who received autologous UCB stem‐cell therapy. Study Type Prospective. Population A cohort of eight pediatric CP patients (2.6 ± 0.6 years of age) with intact corticospinal tracts (CST) from a randomized, placebo‐controlled trial of autologous UCB stem‐cell therapy in CP children was included in this study. Field Strength/Sequence DTI and 3D spoiled gradient recalled (SPGR) QSM at 3.0T. Assessment Pre‐ and posttreatment magnetic susceptibility (χ) and the rotationally‐invariant magnetic susceptibility anisotropy (MSA) along the CST were derived. Behavioral changes were assessed using the 66‐item Gross Motor Function Measurement. Changes in χ and MSA were compared between patients with and without substantial behavioral improvements. Statistical Tests Two‐sample t ‐tests were performed to assess the differences in the changes of measurements of interest (Δχ, ΔMSA, and ΔFA) between patients who significantly improved and those who did not. Results Patients who demonstrated posttreatment motor improvements exceeding expectations showed significantly more diamagnetic Δχ in the periventricular region along the CST ( P = 0.003). Further analysis on the ΔMSA of this region was significantly increased ( P = 0.006) for high responders, along with concurrent FA increase. Data Conclusion These initial findings suggest that the DTI tract‐based QSM method has the potential to characterize white matter changes associated with behavioral improvements in CP children who underwent cord blood stem‐cell therapy. Level of Evidence 2 Technical Efficacy Stage 2