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Role of MRI to Assess Response to Neoadjuvant Therapy for Breast Cancer
Author(s) -
Reig Beatriu,
Heacock Laura,
Lewin Alana,
Cho Nariya,
Moy Linda
Publication year - 2020
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.27145
Subject(s) - medicine , breast cancer , neoadjuvant therapy , radiogenomics , mammography , radiology , magnetic resonance imaging , breast mri , stage (stratigraphy) , diffusion mri , radiomics , medical physics , cancer , paleontology , biology
The goals of imaging after neoadjuvant therapy for breast cancer are to monitor the response to therapy and facilitate surgical planning. MRI has been found to be more accurate than mammography, ultrasound, or clinical exam in evaluating treatment response. However, MRI may both overestimate and underestimate residual disease. The accuracy of MRI is dependent on tumor morphology, histology, shrinkage pattern, and molecular subtype. Emerging MRI techniques that combine functional information such as diffusion, metabolism, and hypoxia may improve MR accuracy. In addition, machine‐learning techniques including radiomics and radiogenomics are being studied with the goal of predicting response on pretreatment imaging. This article comprehensively reviews response assessment on breast MRI and highlights areas of ongoing research. Level of Evidence 3 Technical Efficacy Stage 3 J. MAGN. RESON. IMAGING 2020;52:1587–1606.