Premium
Long‐term reactions to pulsatile tinnitus are marked by weakened short‐range functional connectivity within a brain network in the right temporal lobe
Author(s) -
Zheng Wang,
Peng Zhang,
Pengfei Zhao,
Jing Li,
Heyu Ding,
Hongxia Yin,
Yawen Liu,
Zhengyu Zhang,
Shusheng Gong,
Zhenghan Yang,
Han Lv,
Zhenchang Wang
Publication year - 2019
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.26545
Subject(s) - pulsatile flow , temporal lobe , tinnitus , term (time) , functional connectivity , neuroscience , medicine , audiology , cardiology , psychology , physics , astronomy , epilepsy
Background There have been recent efforts to characterize brain functional activity features in patients with pulsatile tinnitus (PT). These efforts have revealed evidence of aberrant functional connectivity (FC) of the right middle temporal gyrus (MTG) in PT patients with prolonged disease duration. Purpose To assess the possible predictive effect of aberrant FC of MTG in PT patients with prolonged disease duration. Study Type Retrospective. Population Thirty‐four patients with recent‐onset PT (RPTIN), 24 patients with long‐term PT (LPTIN), and 35 age‐, gender‐, and education‐matched healthy controls were enrolled. Field Strength/Sequence 3.0T MRI system and echo‐planar imaging (EPI) sequence, 3D brain volume imaging (BRAVO) sequence. Assessment Functional MRI data preprocessing was performed in Data Processing & Analysis for Brain Imaging (DPABI) and Statistical Parametric Mapping (SPM) 8. The FC analyses were conducted using the software REST. Statistical Tests One‐way analysis of covariance was conducted between three groups with age and gender as covariates, and post‐hoc analysis was used to identify the sources of group effects. Pearson's correlation analysis was conducted for the z‐values of altered FC strength in the PT group and the clinical data. Results Among hubs belonging to the executive control network, the default mode network (DMN), and limbic network, the strength of FC was mainly decreased in the patient groups compared with normal controls ( P < 0.05). Relative to RPTIN patients and normal controls, LPTIN patients were further characterized by significantly decreased FC between several short‐range brain regions adjacent to the seed ( P < 0.05). Finally, disease duration was negatively correlated with decreased FC between the seed and right fusiform gyrus/parahippocampal gyrus, right inferior frontal gyrus, and right MTG (a brain area adjacent to the seed region). Data Conclusion Long‐term reactions to PT mainly involved weakened short‐range FC, especially within a functional network in the right temporal lobe. Level of Evidence : 4 Technical Efficacy : Stage 2 J. Magn. Reson. Imaging 2018.