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Improvement of reproducibility in quantitative susceptibility mapping (QSM) and transverse relaxation rates ( R 2 * ) after physiological noise correction
Author(s) -
Choi Joon Yul,
Lee Jingu,
Nam Yoonho,
Lee Jongho,
Oh SeHong
Publication year - 2019
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.26522
Subject(s) - reproducibility , white matter , coefficient of variation , nuclear medicine , biomedical engineering , nuclear magnetic resonance , magnetic resonance imaging , medicine , chemistry , radiology , physics , chromatography
Background Numerous studies have suggested that quantitative susceptibility mapping (QSM) and transverse relaxation rates ( R 2 * ) are useful to monitor neurological diseases. For clinical use of QSM andR 2 * , reproducibility is an important feature. However, respiration‐induced local magnetic field variation makes artifacts in gradient echo‐based images and reduces the reproducibility of QSM andR 2 * . Purpose To investigate the improvement of reproducibility of QSM andR 2 *after the correction of respiration‐induced field variation, and to assess the effect of varying types of the region of interest (ROI) analysis on reproducibility. Study Type Reproducibility study. Population Ten controls. Field Strength/Sequence 3T/multiecho gradient echo sequence. Assessment Intrascan reproducibility of QSM andR 2 *was investigated in ROIs before and after the respiration correction. Statistical Tests Reproducibility was obtained by the square of voxel‐wise correlation coefficients between scans. A paired t ‐test was performed for comparison between before and after the respiration correction and between QSM andR 2 * . Results Based on the ROI analysis, reproducibility increased after the respiration correction. Reproducibility in the white matter (11.89% increased in QSM and 23.38% inR 2 * , P = 0.009 and 0.024, respectively) and deep gray matter (5.50% increased in QSM and 13.96% inR 2 * , P = 0.024 and 0.019, respectively) increased significantly after the respiration correction. Reproducibility ofR 2 *was higher than that of QSM in the whole brain and cortical gray matter, while QSM maps showed higher reproducibility thanR 2 *in the white matter and deep gray matter. Data Conclusion Respiration‐induced error correction significantly improved reproducibility in QSM andR 2 *mapping. QSM andR 2 *mapping showed a different level of reproducibility depending on the types of ROI analysis. Level of Evidence: 4 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018.