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Conspicuity of Malignant Liver Tumors on Diffusion‐Weighted Imaging With Short tau Inversion Recovery After Gadolinium Ethoxybenzyl Diethylenetriaminepentaacetic Acid Administration
Author(s) -
Iwanaga Takashi,
Fukukura Yoshihiko,
Saito Tomonori,
Sasaki Masashi,
Kumagae Yuichi,
Takumi Koji,
Hakamada Hiroto,
Fujisaki Takuro,
Saigo Yasumasa,
Yoshiura Takashi
Publication year - 2019
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.26196
Subject(s) - medicine , gadolinium , nuclear medicine , magnetic resonance imaging , hepatocellular carcinoma , chronic liver disease , diffusion mri , radiology , gastroenterology , cirrhosis , chemistry , organic chemistry
Background Diffusion‐weighted imaging (DWI) has been used for the detection and characterization of liver tumors because it has excellent contrast resolution. DWI using short tau inversion recovery (STIR) can improve tumor‐to‐liver contrast after gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd‐EOB‐DTPA) administration that shortens the T 1 relaxation of liver parenchyma. Purpose To quantitatively and qualitatively compare the conspicuity of malignant liver tumors on DWI after Gd‐EOB‐DTPA administration between STIR and chemical shift selective (CHESS) sequences. Study Type Single‐institution retrospective study. Subjects Fifty‐seven patients with histologically confirmed malignant liver tumors were evaluated. Field Strength/Sequence Low b‐value DWIs with STIR and CHESS sequences 18–20 minutes after Gd‐EOB‐DTPA administration were acquired at 1.5T. Assessment Tumor contrast‐to‐noise ratio (CNR) and visual grade of tumor conspicuity on DWI between STIR and CHESS sequences were compared. Statistical Tests Paired Student's t ‐test and the Wilcoxon signed rank‐test were applied. P < 0.05 was considered statistically significant. Results The mean tumor CNR and visual grade of tumor conspicuity on DWI were significantly higher for STIR than for CHESS (both P < 0.001). Regardless of the presence of chronic liver disease, the mean CNR (normal liver 33.5 ± 19.8 vs. 15.7 ± 12.2, P < 0.001; chronic liver disease 19.6 ± 11.0 vs. 9.2 ± 7.8, P < 0.001) and the visual conspicuity grade (normal liver 3.36 ± 0.64 vs. 2.56 ± 0.77, P < 0.001; chronic liver disease 2.94 ± 0.80 vs. 2.25 ± 0.84, P = 0.001) were significantly higher for STIR than for CHESS. Mean CNR and the visual conspicuity grade were also significantly higher for STIR than for CHESS in patients with hepatocellular carcinomas (CNR 18.1 ± 10.5 vs. 8.8 ± 7.2, P < 0.001; visual grade 2.88 ± 0.83 vs. 2.22 ± 0.87, P = 0.001) or metastases (CNR 35.0 ± 19.3 vs. 16.2 ± 13.1, P < 0.001; visual grade 3.45 ± 0.51 vs. 2.59 ± 0.73, P < 0.001). Data Conclusion DWI using STIR may be more helpful for depicting malignant liver tumors after Gd‐EOB‐DTPA administration compared with DWI using CHESS. Level of Evidence: 3 Technical Efficacy : Stage 2 J. Magn. Reson. Imaging 2019;49:565–573.