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Prospective comparison between DCE‐MRR and 99m Tc‐DTPA‐based SPECT for determination of allograft renal function
Author(s) -
WanLi Zhou,
Jun Tao,
YuDong Zhang,
Fei Shuang,
Zhijian Han,
ChenJiang Wu,
Zijie Wang,
Yongjun Li,
Hongliang Que,
Zhengkai Huang,
Zengjun Wang,
Ruoyun Tan,
Min Gu
Publication year - 2019
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.26188
Subject(s) - renal function , nuclear medicine , medicine , single photon emission computed tomography , coefficient of variation , prospective cohort study , correlation coefficient , transplantation , urology , chemistry , mathematics , statistics , chromatography
Background Glomerular filtration rate (GFR) is a preferred indicator of allograft renal function, but direct measurement of GFR remains complicated. Purpose To prospectively compare dynamic contrast‐enhanced MR renography (DCE‐MRR) with 99m Tc‐DTPA‐based single‐photon emission computed tomography (SPECT) for determination of allograft renal function. Study Type Prospective. Population Seventy kidney‐transplant recipients Field Strength A low‐dose DCE‐MRR with a 3.0T scanner and a 99m Tc‐DTPA‐based SPECT after renal transplantation were performed. Assessment A Baumann‐Rudin (BR) and a modified two‐compartment model (JZ2C) were used for DCE‐MRR analysis. Standard Gate's method was used for SPECT analysis. An endogenous creatinine clearance rate (CCr) constituted the reference standard. Statistical Tests Pearson correlation test and Bland–Altman agreement analysis. Results The reference CCr‐GFR was 59.58 ± 23.72 mL/min/1.73 m 2 . GFR determined by eGFR, BR, JZ2C, and SPECT was 90.22 ± 34.38, 36.78 ± 14.46, 48.99 ± 23.88, and 67.32 ± 18.44 mL/min/1.73 m 2 , respectively. DCE‐MRR using JZ2C had the best overall performance, with a Pearson correlation coefficient of 0.81, a bias of –10.58 mL/min/1.73 m 2 , and a precision of 14.61 mL/min/1.73 m 2 , as well as high accuracy (30–50% intervals: 74.3–90.0%). Although SPECT had a small bias (7.74 mL/min/1.73 m 2 ), it had a poor correlation coefficient (0.38), poor precision (23.93 mL/min/1.73 m 2 ), and low accuracy (64.3–72.3%) as compared with DCE‐MRR using JZ2C. Data Conclusion DCE‐MRR using JZ2C is superior to 99m Tc‐DTPA‐based SPECT to determine allograft renal function. Level of Evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:262–269.