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Imaging biomarkers in oncology: Basics and application to MRI
Author(s) -
Dregely Isabel,
Prezzi Davide,
KellyMorland Christian,
Roccia Elisa,
Neji Radhouene,
Goh Vicky
Publication year - 2018
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.26058
Subject(s) - magnetic resonance imaging , personalized medicine , biomarker , cancer , precision medicine , cancer imaging , medicine , medical physics , molecular imaging , pathology , radiology , bioinformatics , biology , biochemistry , microbiology and biotechnology , in vivo
Cancer remains a global killer alongside cardiovascular disease. A better understanding of cancer biology has transformed its management with an increasing emphasis on a personalized approach, so‐called “precision cancer medicine.” Imaging has a key role to play in the management of cancer patients. Imaging biomarkers that objectively inform on tumor biology, the tumor environment, and tumor changes in response to an intervention complement genomic and molecular diagnostics. In this review we describe the key principles for imaging biomarker development and discuss the current status with respect to magnetic resonance imaging (MRI). Level of Evidence 5 Technical Efficacy Stage 5 J. Magn. Reson. Imaging 2018;48:13–26.